Berbamine

Berbamine (CAS No.: 478-61-5) is a bisbenzylisoquinoline natural product extracted from the traditional Chinese medicinal herb Berberis amurensis. Major studies indicate that it has anti-leukemia activity, can inhibit the expression of the bcr/abl fusion gene, and acts as an NF-κB inhibitor; in addition, Berbamine targets Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) to inhibit cancer cell growth and induce apoptosis in human myeloma cells. In in vitro studies, Berbamine shows low-micromolar inhibitory activity against multiple cancer cell lines, with the specific activity level depending on the cell type and experimental conditions. In cell and animal models, Berbamine is commonly used to evaluate its anti-tumor and anti-inflammatory effects, and the doses or concentrations used in experiments typically depend on the experimental design and research objectives.