BDP5290
BDP5290 (CAS No.: 1817698-21-7) is a potent small-molecule inhibitor targeting Rho-associated protein kinases (ROCK1 and ROCK2) and myotonic dystrophy kinase-related Cdc42-binding kinases (MRCKα and MRCKβ), key regulators of cytoskeletal dynamics and cell motility. It exhibits high inhibitory activity in the nanomolar range, with IC50 values of approximately 5 nM for ROCK1, 50 nM for ROCK2, 10 nM for MRCKα, and 100 nM for MRCKβ, indicating strong potency across these related serine/threonine kinases. By modulating signaling pathways associated with actomyosin contractility, cell shape, and migration, BDP5290 serves as a valuable research tool for investigating mechanisms of cytoskeletal organization, cell invasion, and metastasis-related processes in various cellular systems. This compound is widely applied in biochemical assays and cell-based models to study kinase signaling networks and to evaluate the role of ROCK and MRCK pathways in disease-relevant contexts, with experimental concentrations varying depending on assay conditions and specific research objectives.
| Physical Appearance | Solid |
| Storage | -20°C |
| M.Wt | 371.82 |
| Cas No. | 1817698-21-7 |
| Formula | C17H18ClN7O |
| Solubility | ≥38 mg/mL in DMSO |
| Chemical Name | 4-chloro-1-(piperidin-4-yl)-N-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)-1H-pyrazole-3-carboxamide |
| Canonical SMILES | ClC1=CN(C2CCNCC2)N=C1C(NC3=CNN=C3C4=NC=CC=C4)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
