Azido-PEG1-Val-Cit-PABC-PNP

Azido-PEG1-Val-Cit-PABC-PNP is a cleavable ADC linker containing a single PEG unit, which also possesses click chemistry reagent properties. It is primarily used for the synthesis of antibody-drug conjugates (ADCs). Mechanistically, its azide group can couple with alkyne-containing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC), and can also efficiently react with DBCO or BCN groups through strain-promoted azide-alkyne cycloaddition (SPAAC). The PEG1 spacer arm optimizes water solubility and reduces steric hindrance, while the PNP active end allows rapid conjugation with amine-containing drug payloads. After the ADC is internalized by tumor cells, lysosomal cathepsin B specifically cleaves the Val-Cit dipeptide sequence (Product No.: BA2571), followed by self-immolative dissociation of the PABC group to release the active drug. The core functions focus on targeted and precise conjugation as well as controlled drug release. Applications include tumor-targeted ADC construction, bioorthogonal labeling and in vivo imaging, and modification of nanodrug delivery systems. Additionally, it offers good plasma stability and biocompatibility.