Avatrombopag
Catalog No.
BA6278
Avatrombopag (AKR-501) is an orally active non-peptide thrombopoietin receptor agonist (=3.3 nM).
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Avatrombopag (AKR-501) is an orally active nonpeptide thrombopoietin receptor agonist (=3.3 nM).Avatrombopag mimics the biological activity of TPO.Avatrombopaghydrochloride increases platelet production through activation of the intracellular signaling system and promotes platelet and megakaryocyte production by hematopoietic precursor cells. Avatrombopaghydrochloride increases platelet production by activating the intracellular signaling system and promotes the production of platelets and megakaryocytes by hematopoietic precursor cells.Avatrombopag is a substrate for cytochrome P450 (CYP) 2C9 and CYP3A.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 649.65 |
| Cas No. | 570406-98-3 |
| Formula | C29H34Cl2N6O3S2 |
| Synonyms | AKR-501;E5501;YM477 |
| Solubility | ≥16.8 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid |
| Canonical SMILES | O=C(O)C1CCN(C2=NC=C(C=C2Cl)C(=O)NC3=NC(C=4SC=C(Cl)C4)=C(S3)N5CCN(CC5)C6CCCCC6)CC1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
