APTO-253
Catalog No.
BA2741
APTO-253 (LOR-253) is a small molecule that inhibits expression, stabilizes G-quadruplex DNA and induces cell cycle arrest and apoptosis in AML cells.
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APTO-253 (LOR-253) is a small molecule that inhibits the expression, stabilizes G-quadruplex DNA and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.APTO-253 mediates anticancer activity by inducing the Kruppel-likefactor4 oncogenic factor.APTO-253 exhibits anti-arthritic activity.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 367.38 |
| Cas No. | 916151-99-0 |
| Formula | C22H14FN5 |
| Synonyms | LOR-253;LT-253 |
| Solubility | ≥50.8 mg/mL in DMSO; ≥2.64 mg/mL in EtOH with gentle warming and ultrasonic; insoluble in H2O |
| Chemical Name | 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline |
| SDF | Download SDF |
| Canonical SMILES | CC1=C(C(C=C(F)C=C2)=C2N1)C(N3)=NC4=C3C5=CC=CN=C5C6=NC=CC=C64 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
