Anti-TRIM23 Rabbit Monoclonal Antibody
Catalog No.
MA5539
Anti-TRIM23 Rabbit Monoclonal Antibody
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Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).
373
ARD1; ARFD1; RNF46
Rabbit
Human, Mouse, Rat
Unconjugated
Calculated MW: 64 kDa; Observed MW: 64 kDa
Unmodified
IgG
Monoclonal Antibody
AP-19D3C12
Liquid
See label
Carrier Not Free
A synthetic peptide of human TRIM23
Affinity Purified
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA.
WB
Blue ice
-20°C
12 months
Please avoid freeze-thaw cycles.