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Anti-TNFRSF12A/TWEAKR/CD266 Antibody (Enavatuzumab)

Catalog No.
F1057
Anti-TNFRSF12A/TWEAKR/CD266 Antibody (Enavatuzumab)
Grouped product items
SizePriceStock Qty
100ug
$90.00
Ship with 3-5 days
1mg
$270.00
Ship with 3-5 days
5mg
$702.00
Ship with 3-5 days
50mg
$2,359.00
Ship with 3-5 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody that targets the TNF-like weak inducer of apoptosis receptor (TWEAK). TWEAK (Fn14; TNFRSF12A) is the natural ligand of the TWEAK receptor (TweakR) and stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody-dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruit and activate myeloid effector cells to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo.

Quality Control

Quality Control & DataSheet

View current batch:
 

M.Wt

150 kDa

Shipping

Dry ice

Cas No.

1062149-33-0

Storage

-80°C

Expiration Date

2 years

Form

Liquid

Concentration

See label

Reconstitution

For reconstitution, we recommend adding sterile, distilled water to achieve a final antibody concentration. Gently shake it to solubilize the protein completely. Do not vortex.

Host

CHO

Alternative Names

PDL-192, Enavatuzumab

Buffer System

100 mM Pro 20 mM Arg pH 5.0. No preservative!

Target Accession

Q9NP84

Reactivity

Human

Conjugation

Unconjugated

Clonality

Monoclonal

Purification

Protein A

Isotype

IgG1

Application

ELISA, FACS, Kinetics, Functional assay, Animal Model

Biological Activity

Human TNFRSF12A / TWEAKR / CD266 HEK293 Cell Line were stained with Anti-TNFRSF12A/TWEAKR/CD266 Antibody (Enavatuzumab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, The EC50 is 0.04694 ug/mL.

Target

TNFRSF12A / TWEAKR / CD266

Note

Please avoid freeze-thaw cycles.