Anti-SNAI1 Rabbit Polyclonal Antibody
Catalog No.
PA1339
Anti-SNAI1 Rabbit Polyclonal Antibody
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Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.
6615
SNAH; Zinc finger protein SNAI1; Protein snail homolog 1; Protein sna
Rabbit
Human, Mouse
Unconjugated
Calculated MW: 29 kDa; Observed MW: 29 kDa
Unmodified
IgG
Polyclonal Antibody
Liquid
See label
Carrier Not Free
The antiserum was produced against synthesized peptide derived from human SNAI1.
Affinity Purified
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
WB, IHC-P, ICC/IF, ELISA
Blue ice
-20°C
12 months
Please avoid freeze-thaw cycles.