Anti-PMS2 Rabbit Monoclonal Antibody
Catalog No.
MA4665
Anti-PMS2 Rabbit Monoclonal Antibody
Featured Products
Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.
5395
DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2
Rabbit
Human
Unconjugated
Calculated MW: 96 kDa; Observed MW: 96 kDa
Unmodified
IgG
Monoclonal Antibody
AP-8A6H5
Liquid
See label
Carrier Not Free
A synthetic peptide of human PMS2
Affinity Purified
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA.
WB, IP
Blue ice
-20°C
12 months
Please avoid freeze-thaw cycles.