Anti-Phospho-TrkA/B (Tyr490/Tyr516) Rabbit Monoclonal Antibody
Catalog No.
MA4568
Anti-Phospho-TrkA/B (Tyr490/Tyr516) Rabbit Monoclonal Antibody
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The family of Trk receptor tyrosine kinases consists of TrkA, TrkB and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA.
4915
NTRK2; TRKB; BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B
Rabbit
Human, Mouse, Rat
Unconjugated
Calculated MW: 92 kDa; Observed MW: 140 kDa
Phosphorylated
IgG
Monoclonal Antibody
AP-10B4E1
Liquid
See label
Carrier Not Free
A synthetic phosphopeptide corresponding to residues surrounding Tyr516 of human TrkB
Affinity Purified
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA.
WB
Blue ice
-20°C
12 months
Please avoid freeze-thaw cycles.