Anti-Phospho-Rb2 p130 (Ser952) Rabbit Monoclonal Antibody
Catalog No.
MA4523
Anti-Phospho-Rb2 p130 (Ser952) Rabbit Monoclonal Antibody
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Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
5934
Rb2; P130
Rabbit
Human
Unconjugated
Calculated MW: 128 kDa; Observed MW: 128 kDa
Phosphorylated
IgG
Monoclonal Antibody
AP-12D11D4
Liquid
See label
Carrier Not Free
A synthetic phosphopeptide corresponding to residues surrounding Ser952 of human Rb2 p130
Affinity Purified
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA.
WB, IHC-F, IHC-P, ICC/IF
Blue ice
-20°C
12 months
Please avoid freeze-thaw cycles.