Anti-PHLPP2 Rabbit Monoclonal Antibody
Catalog No.
MA4323
Anti-PHLPP2 Rabbit Monoclonal Antibody
Featured Products
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427).
23035
PHLPP2; KIAA0931, PHLPPL; PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase-like (PHLPP-like)
Rabbit
Human
Unconjugated
Unmodified
IgG
Monoclonal Antibody
AP-1A6F10
Liquid
See label
Carrier Not Free
A synthesized peptide derived from human PHLPP2
Affinity Purified
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
IHC-P
Blue ice
-20°C
12 months
Please avoid freeze-thaw cycles.