Anti-Nipah virus Glycoprotein G Human Monoclonal Antibody
Nipah virus Glycoprotein G (NiV-G) is an essential viral attachment protein on the envelope surface of Nipah virus, with a molecular weight of approximately 70 kDa. It is displayed on the viral envelope and mechanically mediates viral binding to host cells, serving as the 'key' that initiates infection. The core function of NiV-G is to bind the host cell surface receptors ephrin-B2 and ephrin-B3, thereby mediating viral entry into host cells. This binding activity is a prerequisite for Nipah virus to initiate infection in both human and animal hosts.
NiV-G does not work alone. As part of a complex, it acts in concert with the viral fusion protein F to jointly mediate membrane fusion. G protein is responsible for 'grabbing' the receptor, while F protein is responsible for 'pulling the zipper' of membrane fusion, and the two cooperate to complete viral invasion.
This antibody is a mouse-human chimeric IgG, with the variable region derived from mouse, determining antigen specificity, and the constant region derived from human IgG, determining effector function. The product is primarily intended for ELISA applications
