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Anti-LC3A/B Rabbit Polyclonal Antibody

Catalog No.
PA1195
Anti-LC3A/B Rabbit Polyclonal Antibody
Grouped product items
SizePriceStock Qty
50ul
$210.00
Ship with 3-5 days
100ul
$375.00
Ship with 3-5 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.

Quality Control

Quality Control & MSDS

View current batch:
 

Gene ID

84557/81631

Alternative Names

LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3; MAP1LC3A; LC3B; ATG8F; MAP1LC3B-a; MAP1A/1BLC3; MAP1LC3B

Host

Rabbit

Reactivity

Human, Mouse, Rat

Conjugation

Unconjugated

M.Wt

Calculated MW: 14 kDa; Observed MW: 14,16 kDa

Modification

Unmodified

Isotype

IgG

Clonality

Polyclonal Antibody

Form

Liquid

Concentration

See label

Carrier

Carrier Not Free

Immunogen

Synthetic peptide.

Purification

Affinity Purified

Buffer System

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application

WB

Shipping Condition

Blue ice

Storage

-20°C

Expiration Date

12 months

Note

Please avoid freeze-thaw cycles.