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Anti-IL-3Ra/CD123 Antibody (Talacotuzumab)

Catalog No.
F1218
Anti-IL-3Ra/CD123 Antibody (Talacotuzumab)
Grouped product items
SizePriceStock Qty
100ug
Please inquire
Ship with 3-5 days
1mg
Please inquire
Ship with 3-5 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized CD123 neutralizing monoclonal antibody with a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, and 16.8 nM for CD123, CD32b/c, CD16-158F, and CD16-158V, respectively. Talacotuzumab inhibits the binding of IL-3 to CD123, thereby antagonizing IL-3 signaling in target cells. Talacotuzumab mutates the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in reducing leukemic cell growth in an acute myeloid leukemia (AML) xenograft mouse model in vivo.

Quality Control

Quality Control & DataSheet

View current batch:
 

M.Wt

147.42 kDa

Shipping

Dry ice

Cas No.

1826831-79-1

Storage

-80°C

Expiration Date

2 years

Form

Liquid

Concentration

See label

Reconstitution

For reconstitution, we recommend adding sterile, distilled water to achieve a final antibody concentration. Gently shake it to solubilize the protein completely. Do not vortex.

Host

CHO

Alternative Names

JNJ-56022473, CSL362

Buffer System

100 mM Pro 20 mM Arg pH 5.0. No preservative!

Target Accession

P26951

Reactivity

Human

Conjugation

Unconjugated

Clonality

Monoclonal

Purification

Protein A

Isotype

IgG1

Application

ELISA, FACS, Kinetics, Functional assay, Animal Model

Biological Activity

Immobilized human IL 3Rα His at 2 ug/mL can bind Anti-IL-3Ra/CD123 Antibody (Talacotuzumab)

Target

IL-3Ra / CD123

Note

Please avoid freeze-thaw cycles.