Anti-ICOS/CD278 Antibody (Alomfilimab)
Catalog No.
F1470
Anti-ICOS/CD278 Antibody (Alomfilimab)
Featured Products
KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody directed against the inducible co-stimulatory receptor (ICOS). KY-1044 depletes cells with high ICOS via antibody-dependent cellular cytotoxicity (ADCC) with the engagement of FcgRIIIa. KY-1044 acts as a co-stimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (via FcgR-dependent aggregation). KY-1044 exploits the differential expression of ICOS on T cell subtypes to improve the intratumoral immune environment and restore anti-tumor immune responses.
146.5 kDa
Dry ice
2378692-24-9
-80°C
2 years
Liquid
See label
For reconstitution, we recommend adding sterile, distilled water to achieve a final antibody concentration. Gently shake it to solubilize the protein completely. Do not vortex.
CHO
KY 1044, SAR445256
100 mM Pro 20 mM Arg pH 5.0. No preservative!
Q9Y6W8
Human
Unconjugated
Monoclonal
Protein A
IgG1
ELISA, FACS, Kinetics, Functional assay, Animal Model
The purity of Anti-ICOS/CD278 Antibody (Alomfilimab) is more than 95%, determined by SEC-HPLC.
ICOS / CD278
Please avoid freeze-thaw cycles.