Anti-eIF4E (8C8) Mouse Monoclonal Antibody
Catalog No.
MA2419
Anti-eIF4E (8C8) Mouse Monoclonal Antibody
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eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types.
1977
EIF4E; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein
Mouse
Human, Mouse, Rat
Unconjugated
Calculated MW: 25 kDa; Observed MW: 25 kDa
Unmodified
IgG1
Monoclonal Antibody
AP-17G8D5
Liquid
See label
Carrier Not Free
Purified recombinant human eif4e protein expressed in E.coli.
Affinity Purified
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
WB
Blue ice
-20°C
12 months
Please avoid freeze-thaw cycles.