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Anti-Complement C5 Antibody (Crovalimab)

Catalog No.
F1201
Anti-Complement C5 Antibody (Crovalimab)
Grouped product items
SizePriceStock Qty
100ug
$90.00
Ship with 3-5 days
1mg
$270.00
Ship with 3-5 days
5mg
$702.00
Ship with 3-5 days
50mg
$2,359.00
Ship with 3-5 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Crovalimab (SKY59; RO7112689) is a humanized antibody against C5 in a pH-dependent manner with KD of 15.2nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds to human FcRn with high affinity (KD: 17 μM; pH 6.0). Crovalimab blocks the cleavage of C5 by C5 convertase and inhibits the activity of a C5 variant (p.Arg885His). Crovalimab significantly inhibits the formation of C5b-9 in all three complement pathways, the classical pathway (CP), the lectin pathway (LP), and the alternative pathway (AP). Crovalimab has the potential to be used in the study of paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases.

Quality Control

Quality Control & DataSheet

View current batch:
 

M.Wt

145 kDa

Shipping

Dry ice

Cas No.

1917321-26-6

Storage

-80°C

Expiration Date

2 years

Form

Liquid

Concentration

See label

Reconstitution

For reconstitution, we recommend adding sterile, distilled water to achieve a final antibody concentration. Gently shake it to solubilize the protein completely. Do not vortex.

Host

CHO

Alternative Names

SKY59, RG6107, RO7112689

Buffer System

100 mM Pro 20 mM Arg pH 5.0. No preservative!

Target Accession

P01031

Reactivity

Human

Conjugation

Unconjugated

Clonality

Monoclonal

Purification

Protein A

Isotype

IgG1

Application

ELISA, FACS, Kinetics, Functional assay, Animal Model

Target

Complement C5

Note

Please avoid freeze-thaw cycles.