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Anti-CEACAM5/CEA/CD66e Antibody (Tusamitamab ravtansine)

Catalog No.
F1089
Anti-CEACAM5/CEA/CD66e Antibody (Tusamitamab ravtansine)
Grouped product items
SizePriceStock Qty
100ug
Please inquire
Ship with 3-5 days
1mg
Please inquire
Ship with 3-5 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Tusamitamab ravtansine (SAR408701) is a targeted ADC for CEACAM5-expressing tumor cells, consisting of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent maytansinoid DM4 via a cleavable linker. The average drug-to-antibody ratio (DAR) of tusamitamab ravtansine is 3.8.

Quality Control

Quality Control & DataSheet

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M.Wt

144.52 kDa

Shipping

Dry ice

Cas No.

2254086-60-5

Storage

-80°C

Expiration Date

2 years

Form

Liquid

Concentration

See label

Reconstitution

For reconstitution, we recommend adding sterile, distilled water to achieve a final antibody concentration. Gently shake it to solubilize the protein completely. Do not vortex.

Host

CHO

Alternative Names

SAR408701

Buffer System

100 mM Pro 20 mM Arg pH 5.0. No preservative!

Target Accession

P06731

Reactivity

Human,Cynomolgus [US9617345]

Conjugation

DM4

Clonality

Monoclonal

Purification

Protein A

Isotype

IgG1

Application

ELISA, FACS, Kinetics, Functional assay, Animal Model

Biological Activity

Human CEACAM5 / CEA / CD66e HEK293 Cell Line were stained Anti-CEACAM5 / CEA / CD66e Reference Antibody (Tusamitamab ravtansine) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, The EC50 is 0.61 ug/mL.

Target

CEACAM5 / CEA / CD66e

Note

Please avoid freeze-thaw cycles.