P-selectin, also known as CD62P, is a calcium (Ca²⁺)-dependent transmembrane glycoprotein receptor expressed by myeloid cells. Its function is primarily mediated by recognizing carbohydrate structures on the surface of neutrophils and monocytes. The specific ligand for this receptor is sialyl Lewis X antigen (sLeX), which facilitates adhesive interactions between activated endothelial cells or platelets and white blood cells. During the initial phase of the inflammatory response, P-selectin binds to P-selectin glycoprotein ligand-1 (PSGL1) on the surface of white blood cells, mediating their rapid rolling along the vascular endothelium. This process lays the foundation for subsequent leukocyte adhesion, migration, and inflammatory infiltration.
Description
SwissProt ID: P16109
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Related Biological Data
Related Biological Data
Related Biological Data
Related Biological Data
Gene ID
6403
Alternative Names
SELP; GMRP; GRMP; P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P
Host
Rabbit
Reactivity
Human,Mouse,Rat
Conjugation
Unconjugated
M.Wt
Calculated MW: 91 kDa; Observed MW: 91 kDa
Modification
Unmodified
Isotype
IgG
Clonality
Polyclonal Antibody
Form
Liquid
Concentration
See label
Carrier
Carrier Not Free
Immunogen
The antiserum was produced against synthesized peptide derived from the N-terminal region of human SELP.
Purification
Affinity Purified
Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
