Anti-APPBP1 Rabbit Monoclonal Antibody
Catalog No.
MA1280
Anti-APPBP1 Rabbit Monoclonal Antibody
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Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
8883
NEDD8 activating enzyme E1 subunit 1; HPP1; ula-1; APPBP1; A-116A10.1
Rabbit
Human
Unconjugated
Calculated MW: 60 kDa; Observed MW: 60 kDa
Unmodified
IgG
Monoclonal Antibody
AP-2G9C7
Liquid
See label
Carrier Not Free
A synthetic peptide of human APPBP1
Affinity Purified
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA.
WB, IP
Blue ice
-20°C
12 months
Please avoid freeze-thaw cycles.