Angiotensin II human acetate
Angiotensin II human acetate (CAS No. 68521-88-0) is the main bioactive peptide in the renin-angiotensin system. As a potent vasoconstrictor, it regulates blood pressure, stimulates the sympathetic nervous system, promotes aldosterone synthesis and kidney function, and induces vascular smooth muscle cell proliferation and collagen synthesis by binding to the G protein-coupled receptors AT1R and AT2R, leading to vascular and myocardial thickening and fibrosis, while also promoting apoptosis and endothelial capillary formation. In in vitro studies, Angiotensin II is commonly used to induce hypertension and cardiac hypertrophy models, and the dose or concentration used in experiments usually depends on the experimental design and research objectives.
| Storage | -80°C, sealed storage, away from moisture and light |
| M.Wt | 1106.23 |
| Cas No. | 68521-88-0 |
| Formula | C52H75N13O14 |
| Synonyms | Ang II acetate; Angiotensin II acetate |
| Chemical Name | (2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-4-yl)methyl)-17-amino-5-((S)-sec-butyl)-1-((S)-2-(((S)-1-carboxy-2-phenylethyl)carbamoyl)pyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-1 |
| SDF | Download SDF |
| Canonical SMILES | CC(O)=O.[H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC1=CC=C(O)C=C1)C(=O)N[C@@]([H])(C(C)CC)C(=O)N[C@@]([H])(CC1=CNC=N1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC1=CC=CC=C1)C(O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |