Angiotensin 1/2 (1-5)
Angiotensin 1/2 (1-5) (CAS: 58442-64-1) is a peptide fragment comprising the first five amino acids (Asp-Arg-Val-Tyr-Ile) of angiotensin I and II, produced by enzymatic cleavage of angiotensinogen via the renin-angiotensin system. This system regulates blood pressure and fluid balance, with angiotensin peptides acting as vasoactive hormones. Angiotensin (1-5) is generated during further processing of angiotensin I/II; it has been studied for its potential modulatory roles in vascular function and renal physiology. The compound is employed in research to investigate mechanisms of peptide hormone signaling, vascular tone regulation, and renin-angiotensin system dynamics.
References:
1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9.
2. Richard A. Preston. et. (1998). “Age-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapy”. JAMA. 1998;280(13):1168-1172.
3. Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL. Harrison's principles of internal medicine. McGraw-Hill Medical.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 664.75 |
| Cas No. | 58442-64-1 |
| Formula | C30H48N8O9 |
| Synonyms | H2N-Asp-Arg-Val-Tyr-Ile-OH |
| Solubility | insoluble in H2O; ≥66.5 mg/mL in DMSO; ≥69.5 mg/mL in EtOH |
| Chemical Name | (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoic acid |
| SDF | Download SDF |
| Canonical SMILES | CCC(C)C(C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
