ADS032
Catalog No.
BA6111
ADS032 is a dual NLRP1 and NLRP3 inhibitor that rapidly, reversibly and stably inhibits inflammasome formation.
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ADS032 is a dual inhibitor of NLRP1 and NLRP3 that rapidly, reversibly and stably inhibits inflammasome formation.ADS032 reduces IL-1β and TNF-α secreted and matured by NLPR1 and NLRP3 activation of human-derived macrophages and bronchial epithelial cells, and reduces NLRP3-induced ASC speck formation.ADS032 protects mice against the lethal influenza A virus, reducing lung inflammation and improving their survival.ADS032 inhibited induced IL-1β secretion with IC50s of 94.6 μM (Nowashout) and 354 μM (Washout), respectively.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 403.53 |
| Cas No. | 2757333-37-0 |
| Formula | C22H29NO4S |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |