(±)9(10)-EpOME

(±)9(10)-EpOME (CAS No.: 6814-52-4) is an epoxy fatty acid derived from the cytochrome P450-mediated oxidation of linoleic acid and represents a key intermediate within lipid metabolic pathways. As a member of the epoxy-octadecenoic acid family, this bioactive lipid participates in the regulation of inflammatory responses, intracellular signaling cascades, and oxidative stress-related processes. It is further metabolized by soluble epoxide hydrolase (sEH) to form corresponding dihydroxylated derivatives, such as DiHOME, which have been implicated in modulating mitochondrial function, ion homeostasis, and cellular permeability. Mechanistically, (±)9(10)-EpOME is associated with lipid signaling networks that influence redox balance and membrane dynamics, and it is frequently studied in the context of eicosanoid-like signaling and metabolic stress responses. In vitro studies typically employ concentrations in the nanomolar to micromolar range, depending on the cellular system and experimental design, to investigate its effects on cell viability, signaling pathways, and metabolic regulation. This compound is widely utilized in biochemical and pharmacological research, including studies using cell-based assays and animal models, to elucidate the roles of lipid epoxides in physiological and pathophysiological processes and to support the exploration of sEH-related pathways in drug discovery.