6α-Methylprednisolone 21-hemisuccinate
6α-Methylprednisolone 21-hemisuccinate (CAS No.: 2921-57-5) is a synthetic glucocorticoid prodrug that is hydrolyzed by esterases in vivo to generate the active metabolite methylprednisolone. The latter binds to intracellular glucocorticoid receptors, regulates gene transcription, and exerts anti-inflammatory and immunosuppressive effects. In in vitro experiments, this compound shows activity in the nanomolar to low micromolar range, with specific activity depending on experimental conditions and cell type. It has relatively high water solubility and is commonly used in cell culture and animal model studies to evaluate its anti-inflammatory effects and pharmacokinetic properties. The dose or concentration used in experiments typically depends on the experimental design and research objectives.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 474.54 |
| Cas No. | 2921-57-5 |
| Formula | C26H34O8 |
| Synonyms | Methylprednisolone 21-succinate; MPS |
| Solubility | ≥54 mg/mL in DMSO; ≥10.36 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | 4-(2-((6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)-4-oxobutanoic acid |
| Canonical SMILES | O=C1C=C[C@]2(C([C@H](C[C@@]3([C@@]2([C@H](C[C@]4([C@]3(CC[C@@]4(C(COC(CCC(O)=O)=O)=O)O)[H])C)O)[H])[H])C)=C1)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |