4-Trifluoromethylsalicylic acid

4-Trifluoromethylsalicylic acid (CAS No.: 328-90-5) is a salicylic acid–derived small molecule widely utilized in biomedical research as a platelet aggregation inhibitor and as a versatile scaffold in drug discovery. Functionally, it is known to modulate cyclooxygenase activity in platelets, leading to reduced thromboxane A2 production and subsequent attenuation of platelet activation and aggregation, thereby serving as a valuable tool for investigating platelet biology and eicosanoid signaling pathways. In experimental systems, its activity is generally observed within low micromolar concentration ranges, although effective concentrations vary depending on assay conditions and model systems. This compound is frequently employed in in vitro studies and animal models to explore mechanisms underlying thrombosis, cardiovascular and cerebrovascular pathophysiology, as well as the interplay between inflammatory mediators and platelet function. In addition to its pharmacological relevance, it is also used as a fragment molecule for molecular design, enabling chemical modification, structure–activity relationship studies, and the development of novel bioactive compounds in medicinal chemistry and related research fields.