4-Thiazolecarboxylic acid
Catalog No.
A9084
NCATS-SM1441 (compound 52) is a lactate dehydrogenase (LDH) inhibitor (IC50=40 nM). By inhibiting the activity of LDH, NCATS-SM1441 is able to reduce the production of lactic acid in cancer cells, helping to slow or stop the proliferation of cancer cells.
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NCATS-SM1441 HCl is a novel and first-in-class lactate dehydrogenase (LDH) inhibitor that shows direct target engagement in human tumor xenografts. LDH catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important role in the metabolic plasticity of cancer cells and has long been recognized as a potential therapeutic target. Thus, potent, selective inhibitors of LDH represent an attractive therapeutic approach. However, to date, pharmacological agents have failed to achieve significant target engagement in vivo, possibly because the protein is present in cells at very high concentrations.
| Storage | Store at -20°C |
| M.Wt | 632.74 |
| Cas No. | 1964517-04-1 |
| Formula | C31H25FN4O4S3 |
| Synonyms | NCATS-SM1441, Lactate Dehydrogenase Inhibitor |
| Solubility | Soluble in DMSO |
| Chemical Name | 2-(5-(cyclopropylmethyl)-4-(3-fluoro-4-sulfamoylbenzyl)-3-(3-((5-methylthiophen-2-yl)ethynyl)phenyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | FC1=CC(CC2=C(CC3CC3)N(C4=NC(C(O)=O)=CS4)N=C2C5=CC(C#CC6=CC=C(C)S6)=CC=C5)=CC=C1S(N)(=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
