4-ethylphenyl sulfate
4-Ethylphenyl sulfate is a microbiota-derived metabolite structurally related to p-cresol (4-methylphenol) and classified as a uremic toxin. Elevated serum concentrations have been detected in chronic renal failure patients, suggesting potential utility as a biomarker for renal function. In murine models of autism induced by maternal immune activation (MIA), serum levels of 4-ethylphenyl sulfate significantly increased. Administration to healthy mice induced anxiety-like behaviors and amplified startle sensitivity without affecting pre-pulse inhibition, indicating involvement in behavioral and neurological modulation. This compound serves as a promising research tool for studying gut microbiota-brain interactions in autism-spectrum disorders and renal dysfunction.
- 1. Mehdi Ghaffari Sharaf, Shuhui Li, et al. "Hemocompatibility of cyclodextrin - coated magnetic nanoparticles under uremic conditions." Carbohydr Polym. 2025 Oct 15:366:123836 PMID: 40733788
- 2. Indu Sharma, Agatha Milley, et al. "Binding Capacity and Adsorption Stability of Uremic Metabolites to Albumin-Modified Magnetic Nanoparticles." Int J Mol Sci. 2025 Jun 3;26(11):5366 PMID: 40508174
- 3. Muzammil Kuddushi, Aishwarya S Pawar, et al. "Transparent Janus Nanofibers for Use in Blood - Contact Applications." Langmuir. 2025 May 20;41(19):12030-12037 PMID: 40333017
- 4. Muzammil Kuddushi, Aishwarya Pawar, et al. "Evaluating electrospun polycaprolactone fibers for blood-contacting applications." Biopolymers. 2025 Mar;116(2):e23656 PMID: 39840712
- 5. Aishwarya Shrikrishna Pawar. "Polyethylene Oxide Chain Density and Uremic Toxin Effects on Plasma Protein Adsorption." 2024
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 202.23 |
| Cas No. | N/A |
| Formula | C8H10O4S |
| Solubility | insoluble in EtOH; ≥20.2 mg/mL in DMSO; ≥28.25 mg/mL in H2O |
| Chemical Name | 4-ethylphenyl hydrogen sulfate |
| SDF | Download SDF |
| Canonical SMILES | OS(OC1=CC=C(CC)C=C1)(=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
