3'-dATP
Catalog No.
B8131
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3'-dATP is a synthetic nucleotide analog structurally derived from deoxyadenosine triphosphate (dATP), characterized by the removal of the 3'-hydroxyl group on the ribose sugar. This modification prevents additional nucleotides from forming phosphodiester bonds during DNA synthesis, thereby terminating DNA strand elongation once incorporated by DNA polymerases. Due to this mechanism, 3'-dATP is utilized experimentally to investigate DNA polymerase substrate specificity, enzyme-mediated polymerization processes, DNA replication fidelity, and DNA repair pathways, as well as serving as a tool for enzymatic assays and DNA sequencing studies.
| Physical Appearance | Solution |
| Storage | Store at -20°C or below |
| M.Wt | 491.1 (free acid) |
| Formula | C10H16N5O12P3 (free acid) |
| Synonyms | 3'-Deoxyadenosine-5'-Triphosphate |
| Chemical Name | lithium (5-(6-amino-9H-purin-9-yl)-4-hydroxytetrahydrofuran-2-yl)methyl triphosphate |
| SDF | Download SDF |
| Canonical SMILES | NC1=NC=NC2=C1N=CN2C3C(O)CC(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O3.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = ≥90% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
