2'-O-Methyl-UTP
Catalog No.
B7971
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2'-O-Methyl-UTP is a chemically modified analog of uridine triphosphate (UTP), in which the 2'-hydroxyl group of the ribose sugar is replaced by a methyl group. This structural alteration confers enhanced resistance to nuclease degradation, thereby improving the stability of RNA molecules. Due to its heightened stability, 2'-O-Methyl-UTP is frequently incorporated into RNA oligonucleotides for RNA interference (RNAi), antisense oligonucleotide research, and mRNA modification studies. Its application extends broadly to investigations involving gene expression regulation, RNA therapeutic designs, and nucleic acid delivery platforms in molecular biology and biomedicine.
| Physical Appearance | Solution |
| Storage | Store at -20°C or below |
| M.Wt | 498.2 (free acid) |
| Formula | C10H17N2O15P3 (free acid) |
| Synonyms | 2'-O-Methyluridine-5'-Triphosphate, 2'OMe-UTP |
| Chemical Name | lithium (5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)methyl triphosphate |
| SDF | Download SDF |
| Canonical SMILES | O=C(C=CN1C2C(OC)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O2)NC1=O.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = ≥90% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
