2'-F-dGTP
Catalog No.
B7962
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2'-F-dGTP (2'-Fluoro-2'-deoxyguanosine triphosphate) is a chemically modified deoxynucleotide analog commonly employed in nucleic acid research. It contains a fluorine substitution at the 2' position of the deoxyribose sugar moiety, enabling its incorporation into DNA by polymerases. The incorporation of this modified nucleotide confers enhanced resistance to nuclease-mediated degradation, improving nucleic acid stability. Researchers frequently use 2'-F-dGTP to investigate polymerase specificity, enzymatic mechanism, and to develop antisense oligonucleotides and aptamers with increased biological durability.
| Physical Appearance | Solution |
| Storage | Store at -20°C or below |
| M.Wt | 525.1 (free acid) |
| Formula | C10H15N5O13P3F (free acid) |
| Synonyms | 2'-Fluoro-2'-deoxyguanosine-5'-Triphosphate |
| Chemical Name | lithium (5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl triphosphate |
| SDF | Download SDF |
| Canonical SMILES | O=C1NC(N)=NC2=C1N=CN2C3C(F)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O3.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = ≥95% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
