2-4-Quinolinediol

2-4-Quinolinediol (CAS No.: 86-95-3) is a quinolone-derived small molecule widely utilized as a biochemical reagent and structural scaffold in life sciences research and early-stage drug discovery. It is recognized as a naturally occurring metabolite prominently detected in planktonic cultures of Pseudomonas aeruginosa, where it contributes to quorum sensing-associated signaling networks and is implicated in the maintenance of bacterial pathogenicity under oxygen-limited conditions. Functionally, this compound is associated with microbial communication pathways and redox-related processes, making it a useful probe for studying bacterial physiology, intercellular signaling, and adaptive responses to environmental stress. In biochemical and pharmacological research, it serves as a fragment-like building block for molecular design, enabling scaffold-based optimization, chemical linking, and expansion strategies in the development of novel bioactive compounds. While specific molecular targets and quantitative activity parameters may vary depending on experimental systems, studies involving quinolone analogs typically report biological effects in the nanomolar to micromolar range, particularly in assays evaluating microbial growth modulation and signaling interference. This compound is commonly applied in in vitro cell-based assays, microbial culture studies, and structure–activity relationship investigations, as well as in broader screening platforms for compound library development, with experimental concentrations tailored to specific assay conditions and research objectives.