(1R,2S)-1-Amino-2-indanol

(1R,2S)-1-Amino-2-indanol (CAS No.: 136030-00-7) is a stereochemically defined chiral amino alcohol widely employed as a versatile building block in asymmetric organic synthesis and medicinal chemistry research. Owing to its rigid chiral framework and bifunctional amino and hydroxyl groups, it serves as a valuable precursor for the construction of chiral catalysts and ligands that facilitate enantioselective transformations, including asymmetric hydrogenation and transfer hydrogenation reactions. In biochemical and life science contexts, this compound is utilized as a research reagent and intermediate in the synthesis of structurally complex, biologically relevant molecules, particularly those related to neurotransmitter-like scaffolds, thereby supporting studies in neuropharmacological modeling and structure–activity relationship exploration. It has also been applied as a chromophoric and derivatization agent, as well as in sulfonylation-based synthetic strategies, enabling functional modification of target molecules in drug discovery workflows. While it does not act as a direct modulator of specific biological targets, its derivatives and associated catalytic systems are often evaluated in vitro within nanomolar to micromolar concentration ranges depending on the experimental design, particularly in enzyme modeling, ligand screening, and asymmetric synthesis optimization. The concentrations or conditions employed in experimental systems vary according to the intended application, including use in cell-based assays or preparative synthetic protocols, underscoring its role as a foundational tool in chemical biology and pharmaceutical research.