13(Z)-Docosenoic Acid

13(Z)-Docosenoic Acid (CAS No.: 112-86-7) is a naturally occurring monounsaturated fatty acid, commonly known as erucic acid, isolated from the seeds of Raphanus sativus L. and other plant sources, and is widely studied in lipid metabolism and neurobiology research. This long-chain fatty acid readily crosses the blood–brain barrier and participates in central nervous system lipid homeostasis, where it has been reported to modulate the metabolism and accumulation of very long-chain fatty acids, a process relevant to neuronal integrity and function. Mechanistically, it is associated with the regulation of lipid metabolic pathways, including peroxisomal β-oxidation and elongation systems, thereby influencing membrane composition, signaling lipid balance, and cellular energy dynamics in neural tissues. Through these actions, 13(Z)-Docosenoic Acid has been implicated in maintaining neuronal function and cognitive performance, and is frequently utilized as a tool compound to investigate lipid dysregulation in neurodegenerative disease models and cognitive impairment. While precise molecular targets are not fully defined, its biological effects are typically examined in the context of fatty acid metabolism and associated signaling networks, with experimental applications spanning in vitro cell-based assays and in vivo animal studies, where concentrations or dosing regimens are selected according to specific experimental designs and research objectives, generally within ranges appropriate for evaluating lipid metabolic modulation rather than direct receptor-mediated potency.