11(Z),14(Z),17(Z)-Eicosatrienoic Acid

11(Z),14(Z),17(Z)-Eicosatrienoic Acid (CAS No.: 17046-59-2) is a rare ω-3 polyunsaturated fatty acid that functions as a biologically active lipid regulator with relevance to metabolic and mitochondrial research. Endogenously present at very low abundance in human serum phospholipids, this compound has been shown to modulate lipid metabolic pathways, particularly through inhibition of fatty acid elongation and desaturation processes involved in the conversion of dietary precursors into eicosanoid intermediates. Experimental studies indicate that it supports sustained replication of functional mitochondria in Saccharomyces cerevisiae models, suggesting a role in maintaining mitochondrial integrity and bioenergetic homeostasis. Mechanistically, its activity is associated with modulation of enzyme systems and signaling pathways governing cellular energy metabolism and mitochondrial biogenesis, although precise molecular targets remain to be fully elucidated. Its bioactivity is generally observed in the low micromolar range in vitro, consistent with other polyunsaturated fatty acids influencing enzymatic lipid processing. This compound is widely utilized in biochemical and cell-based assays to investigate mitochondrial dysfunction, lipid metabolism disorders, and regulatory networks involved in energy homeostasis, with experimental concentrations adjusted according to specific model systems and study objectives.