1,2-Dipalmitoyl-sn-glycero-3-PS (sodium salt)

1,2-Dipalmitoyl-sn-glycero-3-PS (sodium salt) (CAS No.: 145849-32-7) is an anionic diacyl phospholipid and a well-defined synthetic form of phosphatidylserine, a negatively charged lipid component predominantly localized to the inner leaflet of eukaryotic cell membranes, where it plays essential roles in membrane structure and signaling regulation. This compound is widely utilized in biochemical and biophysical research as a model phospholipid to investigate membrane asymmetry, lipid–protein interactions, and signaling events associated with phosphatidylserine exposure, including processes involved in apoptosis and cellular recognition. Its physicochemical properties enable its incorporation into lipid bilayers, making it particularly suitable for the preparation of catanionic vesicles and liposomes, thereby supporting studies on membrane fusion, vesicular trafficking, and drug delivery system development. In experimental systems, 1,2-Dipalmitoyl-sn-glycero-3-PS (sodium salt) is employed to probe signaling pathways related to membrane charge distribution and protein recruitment, such as interactions with annexins and other phosphatidylserine-binding proteins, although quantitative activity metrics are generally context-dependent and observed across nanomolar to micromolar concentration ranges in vitro. It is frequently applied in cell-free systems, cultured cell models, and lipid reconstitution assays, with concentrations or formulations tailored to specific experimental objectives, including investigations in neuroscience and apoptosis-related research.