1,2-Dimyristoyl-sn-glycero-3-phosphate (sodium salt)

1,2-Dimyristoyl-sn-glycero-3-phosphate (sodium salt) (CAS No.: 80724-31-8) is a synthetic phosphatidic acid species composed of saturated long-chain myristic acyl groups, widely utilized as a model phospholipid in membrane biology and lipid signaling research. As a member of the phosphatidic acid class, it serves as both a structural intermediate in glycerophospholipid biosynthesis and a bioactive lipid involved in regulating membrane curvature and intracellular signaling processes. This compound is commonly employed in the formation of micelles, liposomes, and other artificial membrane systems, enabling controlled studies of membrane dynamics, lipid–protein interactions, and vesicular trafficking. Functionally, phosphatidic acids are implicated in modulating signaling pathways associated with lipid-metabolizing enzymes and membrane-associated kinases, including pathways linked to phospholipase activity and downstream regulators of cell growth and metabolism, although precise target interactions for this specific species are generally inferred from class behavior rather than fully characterized individually. In vitro, phosphatidic acid analogs typically exhibit modulatory effects in the nanomolar to micromolar range depending on assay conditions and target systems. This reagent is therefore valuable in mechanistic studies of signal transduction, enzyme regulation, and membrane biophysics, as well as in the development of lipid-based drug delivery platforms, where experimental concentrations or formulations are tailored to specific cellular models or biophysical objectives.