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UNC669

In stock
Catalog No.
A8810
L3MBTL antagonist,potent and selective
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$88.00
In stock
10mg
$68.00
In stock
25mg
$110.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

UNC 669 is a potent antagonist of L3MBTL1 (IC50=4.2 μM) and L3MBTL3 (IC50=3.1 μM).

There is less bio-data supported for UNC669. UNC1679 is an analog of UNC669. UNC1215 is the first potent and selective antagonism of a methyl-lysine reader protein, L3MBTL3, which antagonizes the mono- and dimethyl-lysine reading function of L3MBTL3. [1]

Lysine methylation is a key epigenetic landmark, the dysregulation of which is related to many diseases. UNC1679 maintains in vitro and cellular potency with improved selectivity against other MBT-containing proteins. The antagonists described were also found to effectively interact with unlabeled endogenous L3MBTL3 in cells. [1]

Reference:
1.  James LI, Korboukh VK, Krichevsky L et al. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J Med Chem. 2013 Sep 26;56(18):7358-71. doi: 10.1021/jm400919p. Epub 2013 Sep 16.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt338.24
Cas No.1314241-44-5
FormulaC15H20BrN3O
Solubility≥9.35mg/mL in DMSO
Chemical Name(5-bromopyridin-3-yl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
SDFDownload SDF
Canonical SMILESC1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=CN=C3)Br
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description UNC669 is a potent antagonist of L3MBTL with IC50 values of 4.2 µM and 3.1 µM for L3MBTL1 and L3MBTL3, respectively.
Targets L3MBTL1 L3MBTL3        
IC50 4.2 µM 3.1 µM        

Quality Control

Chemical structure

UNC669