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PF-04971729

Catalog No.
A3715
SGLT inhibitor
Grouped product items
SizePriceStock Qty
5mg
$229.00
Ship with 10-15 days
10mg
$347.00
Ship with 10-15 days
50mg
$1,292.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

PF-04971729, a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2, is currently in phase 2 trials for the treatment of diabetes mellitus. Inhibitory effects against the organic cation transporter 2-mediated uptake of [14C]metformin by PF-04971729 also were very weak (IC50 900μM).The disposition of PF-04971729, an orally active selective inhibitor of the sodium-dependent glucose cotransporter 2, was studied after a single 25-mg oral dose of [14C]-PF-04971729 to healthy human subjects. The absorption of PF-04971729 in humans was rapid with a Tmax at ~ 1.0 h. Of the total radioactivity excreted in feces and urine, unchanged PF-04971729 collectively accounted for ~ 35.3% of the dose, suggestive of moderate metabolic elimination in humans.

Chemical Properties

StorageStore at -20°C
M.Wt436.88
Cas No.1210344-57-2
FormulaC22H25ClO7
SynonymsErtugliflozin;PF04971729;PF 04971729
SolubilitySoluble in DMSO
Chemical Name5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
SDFDownload SDF
Canonical SMILESCCOC1=CC=C(CC2=C(Cl)C=CC(C34C(O)C(O)C(O)C(CO4)(CO)O3)=C2)C=C1
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

PF-04971729