DNA Damage/DNA Repair
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
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BA4378 4-MethoxychalconeSummary: 4'-Methoxychalcone regulates adipocyte differentiation through activation. - BA4379 NMS-P515Summary: NMS-P515 is a potent, orally effective, stereotactic inhibitor.
- BA4380 MSC2504877Summary: MSC2504877 (M2912) is a potent, orally active inhibitor with IC values of 0.0007, 0.0008, and 0.54 μM for TNKS, TNKS2, and PARP1, respectively.
- BA4381 5-AIQSummary: 5-AIQ (5-Aminoisoquinolin-1-one) is a water-soluble inhibitor.
- BA4382 PARP-1-IN-4Summary: PARP-1-IN-4 is an inhibitor.
- BA4383 ART-IN-1Summary: An inhibitor.
- BA4384 PARP1-IN-11Summary: PARP1-IN-11 is a potent inhibitor.
- BA4385 2-Methylquinazolin-4-olSummary: 2-Methylquinazolin-4-ol is a potent, competitive inhibitor.
- BA4386 PARP1-IN-7Summary: PARP1-IN-7 is an inhibitor.
- BA4387 Tankyrase-IN-2Summary: Tankyrase-IN-2 is a potent and selective inhibitor (values of 10 nM, 7 nM, and 710 nM for TNKS1, TNKS2, respectively).