DNA Damage/DNA Repair
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
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BA4347 TroxacitabineSummary: A dioxolane analog with potent antitumor activity. -
BA4358 RBN-2397Summary: RBN-2397 is a potent, cross-species, and orally active competitive inhibitor of NAD with values less than 3 nM. - BA4359 PamiparibSummary: Pamiparib (BGB-290) is a potent, highly selective inhibitor with oral activity.
- BA4360 RBN012759Summary: RBN012759 is a potent, selective and orally active inhibitor with values <3nM, 300-fold more selective than for monoPARPs and 1000-fold more selective than for polyPARPs.
- BA4361 SK-575Summary: SK-575 is a highly efficient and specific degrader of protein hydrolysis-targeted chimeras.
- BA4362 RBN-3143Summary: RBN-3143 is a potent inhibitor of NAD+ competitive catalysis.
- BA4363 AZ9482Summary: AZ9482 is a triple inhibitor of PARP1/2/6.
- BA4364 SenaparibSummary: Senaparib (IMP4297) is a potent, selective, and orally effective inhibitor.
- BA4365 iRucaparib-AP6Summary: iRucaparib-AP6 is a highly efficient and specific degrading agent.
- BA4366 VenadaparibSummary: Venadaparib (IDX-1197) is a potent, selective and orally active inhibitor.