3-Deazaadenosine
Catalog No.
B6121
S-Adenosylhomocysteine (SAH) hydrolase inhibitor
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3-Deazaadenosine (CAS 6736-58-9) is an inhibitor of S-adenosylhomocysteine (SAH) hydrolase, an enzyme responsible for the reversible hydrolysis of SAH into adenosine and homocysteine. Inhibition of SAH hydrolase by 3-Deazaadenosine (Ki = 3.9 μM) elevates intracellular SAH concentrations, altering the SAH-to-SAM (S-adenosylmethionine) ratio, and consequently suppressing SAM-dependent methyltransferase activities. In vitro studies demonstrate its antiviral activity against Ebola and Marburg viruses in various primate and mouse cell lines. Animal studies indicate protective efficacy against lethal Ebola infection in BALB/c mice. Currently, 3-Deazaadenosine remains in preclinical research.
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| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 266.25 |
| Cas No. | 6736-58-9 |
| Formula | C11H14N4O4 |
| Solubility | ≥26.6 mg/mL in DMSO; insoluble in EtOH; ≥7.53 mg/mL in H2O with gentle warming |
| Chemical Name | (2R,3R,4S,5R)-2-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol |
| SDF | Download SDF |
| Canonical SMILES | NC1=C2C(N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)=CC=N1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
Related Biological Data
