Sappanone A

Sappanone A (CAS 102067-84-5) is a highly isoflavonoid compound with multiple biological activities, which has been isolated from Caesalpinia pulcherrima, Caesalpinia sappan, and campechianum. In vitro experiments show that at a concentration of 10 μM, Sappanone A inhibits the kinase activities of FGFR1, KDR, c-Met, and c-Kit by 76.2%, 59.2%, 37.4%, and 35.4%, respectively. It can also inhibit influenza virus neuraminidase, with IC50 values against H1N1, H3N2, and H9N2 influenza virus NA of 0.7 μM, 1.1 μM, and 1 μM, respectively. This compound exhibits antibacterial activity against Gram-positive bacteria (Bacillus subtilis, Bacillus sphaericus, Staphylococcus aureus) and Gram-negative bacteria (Klebsiella pneumoniae, Chromobacterium violaceum), and can also inhibit the growth of Aspergillus niger and Candida albicans. In addition, Sappanone A can inhibit lipopolysaccharide (LPS)-induced inflammatory responses both in vitro and in vivo, reduce the production of nitric oxide (NO), interleukin-6 (IL-6, Cat# P1023), and prostaglandin E2 (PGE2, Cat# B7005) in RAW264.7 cells, and decrease LPS-induced mortality in mice. In an ovalbumin-induced asthma mouse model, it can also alleviate airway inflammation and mucus hypersecretion by activating the Nrf2 signaling pathway.

References:

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[4] Lee S, Choi SY, Choo YY, Kim O, Tran PT, Dao CT, Min BS, Lee JH. Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Int Immunopharmacol. 2015 Sep;28(1):328-36. doi: 10.1016/j.intimp.2015.06.015. Epub 2015 Jun 26. PMID: 26122134.

[5] Liu X, Yu D, Wang T. Sappanone A Attenuates Allergic Airway Inflammation in Ovalbumin-Induced Asthma. Int Arch Allergy Immunol. 2016;170(3):180-6. doi: 10.1159/000448331. Epub 2016 Aug 30. PMID: 27576536.