Recombinant Mouse M-CSF/CSF1 (His, Flag)

Macrophage colony-stimulating factor (M-CSF), also known as CSF-1, is a quadruple α helical bundle cytokine that is the main regulator of macrophage survival, proliferation, and differentiation. The M-CSF protein is also essential for the survival and proliferation of osteoclast precursor cells. M-CSF also initiates and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators by macrophages, and stimulates phagocytosis. M-CSF is increased during pregnancy to support the implantation and growth of the decidua and placenta. Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells, and activated endothelial cells. The macrophage colony-stimulating factor receptor (c-FMS) transduces its chemotaxis and mediates its endocytosis. The first 229 amino acids of mouse mature M-CSF have 87%, 83%, 82%, and 81% homology to the corresponding regions of rat, dog, bovine, and human M-CSF, respectively. Human M-CSF is active in mice, but M-CSF from mice has been reported to be species-specific.