Mubritinib (TAK 165)
Catalog No.
B1543
Potent inhibitor of HER2/ErbB2
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Mubritinib (TAK 165; CAS 366017-09-6) is a small molecule inhibitor that selectively targets human epidermal growth factor receptor 2 (HER2/ErbB2). It inhibits HER2 signaling with an IC50 value of approximately 6 nM, demonstrating high potency and specificity. Notably, Mubritinib exhibits negligible activity against other receptor tyrosine kinases, including EGFR, FGFR, PDGFR, and non-receptor kinases such as JAK1, Src, and Blk. Due to its precise targeting of HER2, Mubritinib is valuable for biomedical research investigating HER2-driven cancers and related signaling mechanisms.
| Storage | Store at -20°C |
| M.Wt | 468.47 |
| Cas No. | 366017-09-6 |
| Formula | C25H23F3N4O2 |
| Solubility | insoluble in H2O; ≥76.9 mg/mL in DMSO with gentle warming; ≥3.09 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | 4-[[4-[4-(triazol-1-yl)butyl]phenoxy]methyl]-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
