Caspofungin
Catalog No.
B4972
lipopeptide antifungal drug
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Caspofungin (CAS: 162808-62-0) is a small-molecule inhibitor of β-1,3-glucan synthase, an enzyme essential for the biosynthesis of β-(1,3)-D-glucan, a fundamental cell wall component in pathogenic fungi such as Candida albicans. Caspofungin selectively inhibits β-1,3-glucan synthase activity with a reported IC50 of approximately 0.6 nmol/L in membrane preparations of C. albicans. Caspofungin demonstrates potent antifungal activity against various Candida isolates, including azole-resistant strains (MIC90 ≤0.5 μg/mL), and shows prolonged post-antifungal effects lasting 6–8 hours. It is widely utilized in biomedical research involving fungal infections and antifungal therapeutics.
- 1. Christopher Zajac, Nancy E. Scott, et al. "Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolates." NPJ Antimicrob Resist. 2025 Apr 17;3(1):31. PMID: 40247099
- 2. Dante G Calise, Sung Chul Park, et al. "An oxylipin signal confers protection against antifungal echinocandins in pathogenic aspergilli." Nat Commun. 2024 May 4;15(1):3770. PMID: 38704366
- 3. Bao Gia Vu, Lucia Simonicova, et al. "Calcineurin is required for Candida glabrata Pdr1 transcriptional activation." bioRxiv. July 10, 2023
- 4. Naemah Alkhars, Anthony Gaca, et al. "Antifungal Susceptibility of OralCandidaIsolates from Mother-Infant Dyads to Nystatin, Fluconazole, and Caspofungin." J Fungi (Basel). 2023 May 17;9(5):580. PMID: 37233291
- 5. Chengcheng Hu, Mi Zhou, et al. "Coordinated Regulation of Membrane Homeostasis and Drug Accumulation by Novel Kinase STK-17 in Response to Antifungal Azole Treatment." Microbiol Spectr. 2022 Feb 23;10(1):e0012722. PMID: 35196787
- 6. Bao Gia Vu, W. Scott Moye-Rowley. "Azole-resistant alleles ofERG11inCandida glabratatrigger activation of the Pdr1 and Upc2A transcription factors." Antimicrob Agents Chemother. 2022 Mar 15;66(3):e0209821. PMID: 35007132
- 7. Bao Gia Vu, Mark A. Stamnes, et al. "The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways." PLoS Genet. 2021 Sep 30;17(9):e1009582. PMID: 34591857
- 8. Hoyer AR, Johnson CJ, et al. "Echinocandin Treatment of Candida albicans Biofilms Enhances Neutrophil Extracellular Trap Formation." Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00797-18. PMID: 29987146
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1092.33 |
| Cas No. | 162808-62-0 |
| Formula | C53H89N9O15 |
| Solubility | ≥48.1 mg/mL in DMSO |
| Chemical Name | (2R,6S,11R,12R,14aS,15S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-9-(11,13-dimethyl-2-oxopentadecyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)hexadecahydro-1H-dipyrrolo[2,1- |
| SDF | Download SDF |
| Canonical SMILES | O=C([C@@H]1C[C@@H](O)CN1C([C@@H](NC(C2CC(CCCCCCCCC(C)CC(CC)C)=O)=O)[C@@H](C)O)=O)N[C@@H]([C@H](O)[C@@H](O)C3=CC=C(O)C=C3)C(N[C@@H]([C@H](O)CCN)C(N4CC[C@H](O)[C@H]4C(N[C@@H](NCCN)[C@H](O)C2)=O)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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