Signaling pathways
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BA5494 VU0119498Summary: VU0119498 is a pan-G orthotropic modulator (PAM) with values of 6.04, 6.38 and 4.08 μM, respectively. - BA5495 VU0238441Summary: VU0238441 is a pan-muscarinic acetylcholine receptor-positive altered modulator (PAM).
- BA5496 VU6019650Summary: VU6019650 is a potent
- BA5497 VU6028418Summary: VU6028418 is a potent, highly selective antagonist with oral activity.
- BA5498 ML380Summary: ML380 is a potent, subtype-selective and blood-brain-barrier-crossing orthosteric modulator (PAM) with values of 190 and 610 nM for human and rat M5, respectively.
- BA5499 PentoxyverineSummary: Pentoxyverine (Carbetapentane) is an orally active receptor agonist with σ1 values of 41nM, 894nM and 75nM in for σ1, σ2 and guinea pig brain membranes, respectively.
- BA5501 SolifenacinSummary: Solifenacin is a novel muscarinic receptor antagonist.
- BA5502 ImidafenacinSummary: Imidafenacin (KRP-197; ONO-8025) is a potent and selective M3 receptor inhibitor.
- BA5503 DarifenacinSummary: Darifenacin (UK88525) is an M3 muscarinic-type receptor antagonist.
- BA5504 PQCASummary: PQCA is a highly selective and potent modulator of muscarinic receptor-positive mutations.