Setting 
My Cart
Toggle Nav
mobile icon
Close
  • Menu
  • Setting

Stem Cell

Stem cells are a class of undifferentiated cells that are able to differentiate into specialized tissue cell types. There are two types of stem cells: embryonic stem cells (ESC) and adult stem cells (ASC). The ESC is originated from the inner cell of blastocysts, and the ASC is located in specific tissues, such as bone marrow, adipose tissue and blood.

In ESC, BMP/TGF-β signaling pathway plays a key role in maintaining pluripotency and self-renewal. It signals through Smad proteins, and the FGF signaling pathway, which activates the MAPK and Akt pathways. The Wnt signaling pathway also promotes pluripotency. OCT-4, SOX2, and NANOG are three main transcription factors that are expressed and activated by these pathways. Induced pluripotent stem cells (iPSC) are pluripotent cells that can be generated from differentiated cells with forced expression of specific reprogramming factors. Both ESC and iPSC can be induced to develop into distinct cell types that associated with three primary germ layers: ectoderm, mesoderm and endoderm. Signaling pathways that control the development of these cell lineages, including BMP/TGF-β, Notch, Wnt/β-catenin, Hedgehog and Hippo pathways, which regulate cell division, growth and differentiation. Defects in stem cell signaling are related to developmental disorders and cancer.

Items 131-140 of 155

Page
per page
  1. STAT3-IN-1
    BA2797 STAT3-IN-1
    Summary: STAT3-IN-1 is a potent, selective, and orally effective inhibitor with values of 1.82 μM and 2.14 μM in HT29 and MDA-MB231 cells, respectively.
  2. SC-43
    BA2806 SC-43
    Summary: SC-43, a derivative of Sorafenib, is a potent agonist with oral activity.
  3. KY-05009
    BA2865 KY-05009
    Summary: KY-05009 is an ATP-competitive inhibitor.
  4. PTC-028
    BA2872 PTC-028
    Summary: PTC-028 is an orally effective inhibitor of stem cell factor for the study of ovarian cancer.
  5. MBM-55
    BA2886 MBM-55
    Summary: MBM-55 is an effective inhibitor.
  6. DMU-212
    BA2893 DMU-212
    Summary: DMU-212 is a resveratrol methylated derivative with antidisintegrative, antiproliferative, antioxidant and apoptosis-promoting activities.
  7. MY-1076
    BA2899 MY-1076
    Summary: MY-1076 is an inhibitor.
      ≥49.7 mg/mL
  8. γ-Glutamylvaline
    BA3557 γ-Glutamylvaline
    Summary: Gamma-Glutamylvaline is an activator with anti-inflammatory activity.
      ≥19.8 mg/mL
  9. Orobol
    BA3744 Orobol
    Summary: Orobol is a major soy isoflavone with a variety of pharmacological activities, including anti-skin aging and anti-obesity effects.
  10. Givinostat
    BA4122 Givinostat
    Summary: Inhibitors.

Items 131-140 of 155

Page
per page