Ademetionine
Ademetionine (S-adenosylmethionine; SAMe) is a naturally occurring metabolite present in all cells and biological fluids, and acts as a methyl donor in a variety of methylation reactions involving proteins, phospholipids, catecholamines and DNA. Ademetionine exhibits antidepressant activity associated with increases in brain monoamine neurotransmitters and improvement in muscarinic and β-adrenergic receptor functions. In addition, preliminary studies imply that ademetionine exhibits therapeutic potential in the treatment of other central nervous system disorders including dementia, acquired immune deficiency syndrome-associated myelopathy, as well as brain ischemia.
Reference:
1. Bottiglieri T. Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders. Expert Opinion on Investigational Drugs, 1997, 6(4): 417-426.
| Storage | Store at -20°C |
| M.Wt | 398.44 |
| Cas No. | 29908-03-0 |
| Formula | C15H22N6O5S |
| Solubility | insoluble in EtOH; ≥108 mg/mL in H2O; ≥110.8 mg/mL in DMSO |
| Chemical Name | (2S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonio)butanoate |
| SDF | Download SDF |
| Canonical SMILES | C[S+](CC[C@@H](C([O-])=O)N)C[C@H]([C@H]([C@H]1O)O)O[C@H]1[n]1c2ncnc(N)c2nc1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Animal experiment:[1] | |
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Animal models |
Mice and rats |
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Dosage form |
12.5, 25, 50, 100 and 200 mg/kg Subcutaneous injection |
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Applications |
Ademetionine dose-dependently decreased immobility time in the forced swimming test in mice and rats, and the effect could be antagonized by haloperiodol. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Bottiglieri T. Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders. Expert Opinion on Investigational Drugs, 1997, 6(4): 417-426. |
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Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
